Lupus & antiphospholipid syndrome
Aberrant phenotypes of circulating γδ-T cells may be involved in the onset of systemic lupus erythematosus
Authors' conclusion
A broad range of anomalies in the proportions of γδ-T-cell subsets and γδ-T cells in SLE patients may be involved in the pathogenesis of SLE. There is a strong association between Vδ2+ T cells and their Vδ2+NKp30+ T-cell subpopulation and LN occurrence.
Study context
- Population
- Active systemic lupus erythematosus (SLE) patients (new-onset and relapsing) and healthy controls22 assessed before and after treatment
- Exposure
- Active SLE patients vs healthy controls
- SLEn = Sixty
- Healthy controls (HCs)n = One hundredreference
- Outcome
- Circulating γδ-T cells and subsets (flow cytometry)
Methodological detailscase-control, flow cytometry, before-and-after treatment assessment (subset)
- Case-control
- Flow cytometry
- Before-and-after treatment assessment (subset)
Main finding
As reported in the abstract
- Total γδ-T cells among CD3+ T cells significantly lower in SLE than HCs
- Vδ1+ T cells among γδ-T cells significantly greater in SLE than HCs
- Vδ2+ T cells among γδ-T cells significantly lower in SLE than HCs
- PD-1, NKG2D, NKp30 and NKp46 expression in Vδ1+ and Vδ2+ T cells generally significantly increased in SLE, except NKG2D in Vδ2+ T cells
Observational data: associations, not effects.
Further findings
Association with disease activity
- Vδ2+, Vδ1+ and Vδ1+PD-1+ T cells associated with disease activity
Changes with treatment
- Increase in Vδ2+ T-cell frequency and decrease in PD-1 expression by γδ-T cells might be associated with effective treatment
Renal involvement
- Vδ2+ T cells and Vδ2+NKp30+ subpopulation might be associated with renal involvement
Original publication
Aberrant phenotypes of circulating γδ-T cells may be involved in the onset of systemic lupus erythematosus. Lupus. Published 20 March 2024. doi:10.
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