Lupus & antiphospholipid syndrome
Associations between blood IL-33 levels and IL-33 gene polymorphisms with susceptibility to systemic lupus erythematosus: A meta-analysis
Pooled result · Circulating IL-33 levelsResult — go to the resultSMD 2.140 95% CI 1.068–3.212Authors' conclusion
This meta-analysis identified significantly higher levels of circulating IL-33 in patients with SLE as well as an association between IL-33 rs1891385 and SLE.
Study context
- Population
- Patients with systemic lupus erythematosus (SLE) and controls in studies from MEDLINE, EMBASE and Cochrane Library (to May 2023)9 studies
- Comparison
- SLE vs controls
- SLEn = 1,935
- Outcome
- Serum/plasma IL-33 levels and association of IL-33 rs1929992, rs1891385, rs7044343, rs1095498 and rs10975579 polymorphisms with SLE risk
Methodological detailsethnic stratification, subgroup analysis
- Ethnic stratification
- Subgroup analysis
Pooled result
Circulating IL-33 levels
SMD
2.140
95% CI 1.068–3.212
P < 0.001
SLEvs Control
SMD 2.140 (95% CI 1.068–3.212); P < 0.001
As reported in the abstract
Further pooled results
| Outcome | OR (95% CI) | P value |
|---|---|---|
| IL-33 rs1891385 C allele and SLE | 1.525 (11.310–1.777) | P = 0.010 |
IL-33 levels by ethnicity (Asian, European, Arab)
- Increased IL-33 levels in SLE in Asian, European and Arab groups
IL-33 levels in subgroup analyses (sample size, variable adjustment, data format, publication year)
- Significantly higher IL-33 levels in SLE regardless of subgroup
IL-33 rs1891385 C allele and SLE
- Similar association for rs1891385 C/A with homozygote comparisons and dominant and recessive models
IL-33 rs1929992, rs7044343, rs1095498 and rs10975579 and SLE susceptibility
- No association
Original publication
Associations between blood IL-33 levels and IL-33 gene polymorphisms with susceptibility to systemic lupus erythematosus: A meta-analysis. Lupus. Published 30 July 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →