Lupus & antiphospholipid syndrome
Systematic Review of Inequitable Population Representation in Systemic Lupus Erythematosus Clinical Trials
Authors' conclusion
The results of this study reveal disparities in the representation of the SLE disease population in clinical trials, emphasizing insufficient inclusion of Black, Asian, and Hispanic and Latino participants and the disproportionate overrepresentation of White participants.
Study context
- Population
- US SLE clinical trials published January 1, 2018 to December 31, 2023 (MEDLINE and Embase, searched May 2024)18 US SLE clinical trials
- Outcome
- Participation of historically marginalized populations (participant sex, age, racial and ethnic data)
Methodological detailstwo independent reviewers, standardized data extraction
- Two independent reviewers
- Standardized data extraction
Pooled result
As reported in the abstract
Race and ethnicity representation
Overall poor rating for race and ethnicity participation
11 of 18 studies
61.1%
Good rating for race and ethnicity participation
0
Statistically insignificant underrepresentation of Black, Asian and Hispanic populations
14 of 18 studies
77.8%
Further pooled results
Sex and gender representation
- Included population accurately represented the disease population
Inclusion of older adults
- Studies reporting inclusion of older adults
- 0
Original publication
Systematic Review of Inequitable Population Representation in Systemic Lupus Erythematosus Clinical Trials. Arthritis Care Res (Hoboken). Published 1 August 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →