Lupus & antiphospholipid syndrome
Cardiovascular risk factors and complications in patients with systemic lupus erythematosus with and without nephritis: a systematic review and meta-analysis
Authors' conclusion
Patients with SLE with LN show increased risk of CV risk factors including DM, HT and hyperlipidaemia.
Study context
- Population
- Patients with SLE with or without lupus nephritis (LN); studies published 1947–2022 (PubMed, EMBASE, MEDLINE, Scopus)58 studies evaluated
- Comparison
- SLE with LN vs SLE without LN
- Outcome
- Cardiovascular (CV) risk factors and complications
Methodological detailstwo-arm meta-analysis, proportional meta-analysis
- Two-arm meta-analysis
- Proportional meta-analysis
Pooled result
As reported in the abstract
CV risk factors
LN vs Without LNOdds ratio (95% CI)P value
Hypertension; I2=56%
4.93(3.17–7.65)
P < 0.00001Hyperlipidaemia; I2=0%
11.03(4.20–28.95)
P < 0.00001DM; I2=32%
1.88(1.09–3.25)
P = 0.02Further pooled results
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| MII2=78%; comparator printed as general patients with SLE | 1.35 (0.53–3.45) | P = 0.52 | |
| Cerebrovascular accidentI2=23%; comparator printed as general patients with SLE | 1.64 (0.79–3.39) | P = 0.27 | |
| 0.20.5125Odds ratio (log scale) |
CV mortality incidence rate
Original publication
Cardiovascular risk factors and complications in patients with systemic lupus erythematosus with and without nephritis: a systematic review and meta-analysis. Lupus Sci Med. Published 21 March 2024. doi:10.
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