Lupus & antiphospholipid syndrome
Disease characteristics and outcomes of lupus nephritis in Saudi Arabia: A systematic review
Authors' conclusion
LN is highly prevalent in lupus Saudi patients, with Class IV LN being the most common and associated with poor outcomes. Although survival has improved, many patients still progress to ESRD.
Study context
- Population
- Patients with LN in Saudi Arabia; MEDLINE, ScienceDirect, Embase, Cochrane and PubMed searched up to April 202436 studies
- Outcome
- Disease characteristics and outcomes of LN in Saudi Arabia
Pooled result
As reported in the abstract
- Prevalence of LN among systemic lupus erythematosus (SLE) patients
- 19% to 55%
- Biopsy-proven LN
- 11% to 42.7%
- Females
- 66% to 94.9%
- Mean age at diagnosis (years)
- 23.8 and 39.7
- Hypertension
- 45.8% to 62.9%
- Nephrotic-range proteinuria
- 20.7% to 58.5%
- Mean serum creatinine (µmol/L)
- 60 and 112.68
- Class IV LN, the most common histopathological finding
- up to 72%
- Complete remission within 12 months (lower in proliferative LN)
- up to 81.5%
- End-stage renal disease (ESRD) rates (predictors: proliferative LN, older age, hypertension)
- 5.5% to 30.7%
- Five-year survival
- 92% to 96%
- 10-year survival
- 95%
Original publication
Disease characteristics and outcomes of lupus nephritis in Saudi Arabia: A systematic review. Lupus. Published 18 July 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →