Lupus & antiphospholipid syndrome
COVID-19 vaccine-induced systemic lupus erythematosus: The underlying immunological and genetic mechanisms
Authors' conclusion
This study deepens the underlying mechanism and highlights the importance of evaluating the genetic susceptibility to autoimmune disease before COVID-19 vaccination.
Study context
- Population
- COVID-19 vaccine-induced SLE
- Outcome
- Molecular mechanism of COVID-19 vaccine-induced SLE
Methodological detailswhole genome sequencing, immune cell RNA sequencing of CD4+ T, CD8+ T and B cells
- Whole genome sequencing
- Immune cell RNA sequencing of CD4+ T, CD8+ T and B cells
Main finding
As reported in the abstract
- In genetically predisposed individuals, COVID-19 vaccination might provoke SLE by triggering host-harbored virus signaling and cytokine pathway-associated immune response
Original publication
COVID-19 vaccine-induced systemic lupus erythematosus: The underlying immunological and genetic mechanisms. Lupus. Published 17 July 2025. doi:10.
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