Lupus & antiphospholipid syndrome
Molecular mechanisms underlying thrombosis in systemic lupus erythematosus – A Systematic review
Authors' conclusion
Shared mechanisms between aPL and other autoantibodies may account for the increased thrombosis risk in aPL-negative SLE patients.
Study context
- Population
- Studies of mechanisms contributing to thrombosis risk in systemic lupus erythematosus (SLE) across five procoagulant domains: autoantibodies (incl. aPL), complement, platelets, endothelium, coagulation
- Participants
- 30 studies
- Outcome
- Thrombosis mechanisms in SLE
Methodological detailsPRISMA, PubMed and Embase without time restrictions, pre-specified risk of bias tool, 3,747 publications initially identified
- PRISMA
- PubMed and Embase without time restrictions
- Pre-specified risk of bias tool
- 3,747 publications initially identified
Pooled result
As reported in the abstract
Distinct thrombosis mechanisms of action identified
6
Studies with robust methodological quality in risk of bias assessment
28
Original publication
Molecular mechanisms underlying thrombosis in systemic lupus erythematosus – A Systematic review. Semin Arthritis Rheum. Published 7 March 2025. doi:10.
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