Lupus & antiphospholipid syndrome
Proteins upregulated in thrombotic antiphospholipid syndrome linked to platelet function in contrast with non-antiphospholipid-related thrombosis: insights from two systematic reviews
Authors' conclusion
Our findings highlight the central role of platelet-related processes in tAPS pathogenesis, distinguishing it from non-aPL thrombosis.
Study context
- Population
- Observational controlled proteomics studies of patients with thrombotic antiphospholipid syndrome (APS) and of patients with non-aPL thrombosis7 and 13 studies included
- Comparison
- Thrombotic APS vs non-aPL-related thrombosis
- Thrombotic APS (tAPS)n = seven
- non-aPL thrombosisn = 13reference
- Outcome
- Upregulated proteins in tAPS and non-aPL thrombosis
Methodological detailstwo systematic literature reviews, PRISMA, Gene Ontology (GO) enrichment and network analyses, Records identified: 108 (tAPS) and 209 (non-aPL thrombosis)
- Two systematic literature reviews
- PRISMA
- GO enrichment and network analyses
- Records identified: 108 (tAPS) and 209 (non-aPL thrombosis)
Pooled result
As reported in the abstract
Upregulated proteins identified
tAPS
118
events
Non-aPL thrombosis
319
events
Original publication
Proteins upregulated in thrombotic antiphospholipid syndrome linked to platelet function in contrast with non-antiphospholipid-related thrombosis: insights from two systematic reviews. Lupus Sci Med. Published 7 November 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →