Lupus & antiphospholipid syndrome
Interstitial lung disease in SLE: a 30-year population study
Main finding · ILD IR per 1000 PYResult — go to the resultIncidence rate ratio 26.8Authors' conclusion
ILD occurred more frequently in SLE than the controls with older age, smoking and serositis as risk factors.
Study context
- Population
- Patients with SLE and matched hospitalized controls, Western Australia, 1985–2014
- Participants
- 1,854 vs 12,107
- Exposure
- SLE vs matched hospitalized controls
- SLEn = 1,854
- Controlsn = 12,107reference
- Outcome
- ILD incidence rate per 1000 person years
Methodological detailsmatched hospitalized controls, state-wide longitudinal hospital data, multivariate logistic regression
- Matched hospitalized controls
- State-wide longitudinal hospital data
- Multivariate logistic regression
Main finding
ILD IR per 1000 person years (PY)
Incidence rate ratio
26.8
By group
As reported in the abstract
- Interstitial lung disease (ILD) occurred in SLE patients
- 3.8%
Observational data: associations, not effects.
Further findings
Mortality rate per 1000 PY — SLE-ILD vs SLE without ILD
MRR 2.94
| Outcome | MRR |
|---|---|
| Mortality rate per 1000 PYSLE-ILD vs Controls with ILD | 2.28 |
Time to ILD from index
- Shorter in SLE
Risk factors for ILD
- Older age, smoking and serositis
Survival and cause of death
- ILD decreased survival for SLE and control cohorts; respiratory causes of death predominated in both ILD groups
Original publication
Interstitial lung disease in SLE: a 30-year population study. Rheumatology (Oxford). Published 7 November 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →