Lupus & antiphospholipid syndrome
Circulating biomarkers and detection of pulmonary diseases in patients with systemic lupus erythematosus: A systematic review and meta-analysis of observational studies
Authors' conclusion
Through meta-analyses we identified CB that were significantly associated with PD in SLE including anti-dsDNA. Furthermore, anti-dsDNA, anti-Sm, anti-RNP, and CCL21 were associated with reduced pulmonary function in SLE.
Study context
- Population
- Patients with systemic lupus erythematosus (SLE) in observational studies addressing associations between circulating biomarkers (CB) and pulmonary diseases (PD)
- Participants
- 1,883 patients24 studies
- Comparison
- Circulating biomarkers and detection of pulmonary diseases in SLE
- Outcome
- Associations between CB and PD in SLE
Methodological detailsMEDLINE and EMBASE search, forward and backward citation search, Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2) and Outcome Reporting Bias in Trials (ORBIT) risk-of-bias assessment
- MEDLINE and EMBASE search
- Forward and backward citation search
- QUADAS-2 and ORBIT risk-of-bias assessment
Pooled result
As reported in the abstract
CB significantly associated with PD in individual studies
21
Associations of potential clinical significance in meta-analyses between PD or PD-related outcomes and five CB (anti-dsDNA, anti-RNP, anti-Sm, CCL21, IP-10)
10
Different CB studied
43
Further pooled results
- Anti-dsDNA, anti-Sm, anti-RNP and CCL21 associated with reduced pulmonary function in SLE
Original publication
Circulating biomarkers and detection of pulmonary diseases in patients with systemic lupus erythematosus: A systematic review and meta-analysis of observational studies. Semin Arthritis Rheum. Published 6 November 2025. doi:10.
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