Lupus & antiphospholipid syndrome
Effect of Long‐Term Voclosporin Treatment on Renal Histology in Patients With Active Lupus Nephritis With Repeat Renal Biopsies
Authors' conclusion
Outcomes from this small subgroup show that exposure to study treatment was not associated with nephrotoxicity based on histopathologic evaluation after 18 months.
Study context
- Population
- Patients with active lupus nephritis (LN) in the AURORA trials with baseline and repeat kidney biopsies
- Participants
- 16 vs 10
- Comparison
- Voclosporin vs placebo, both with MMF and low-dose GC, for up to 3 years
- Voclosporinn = 16
- Controln = 10reference
- Primary endpoint
- Change in kidney histology: revised NIH LN activity and chronicity (CI) indices, plus semiquantitative vascular and tubular lesion assessment
- Follow-up
- ≈18 months
Methodological detailsprotocolized repeat kidney biopsies, placebo-controlled
- Protocolized repeat kidney biopsies
- Placebo-controlled
Primary result
As reported in the abstract
Change in chronicity index (CI)
| Group | No change in CI | Change no greater than 2 |
|---|---|---|
| Voclosporin | 8 | 6 |
| Control | 3 | 6 |
No change in CI
Voclosporin8
Control3
Change no greater than 2
Voclosporin6
Control6
Original publication
Effect of Long‐Term Voclosporin Treatment on Renal Histology in Patients With Active Lupus Nephritis With Repeat Renal Biopsies. Arthritis Rheumatol. Published 17 July 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →