Lupus & antiphospholipid syndrome
Systematic review of the reporting of extrarenal manifestations in observational studies of Saudi patients with systemic lupus erythematosus
Authors' conclusion
This study explores the prevalence of extrarenal manifestations of SLE among adult Saudi patients, highlighting significant regional variability in musculoskeletal, dermatological, cardiovascular and neurological symptoms.
Study context
- Population
- Adult patients with SLE in Saudi Arabia; observational or experimental studies of extrarenal manifestations (Medline, ScienceDirect, EBSCO, PubMed up to July 2024)35 studies
- Outcome
- Prevalence rates of extrarenal manifestations of SLE across Saudi cities
Methodological detailsPRISMA, screening, data extraction and quality assessment in duplicate, no time restrictions, Primarily retrospective cohort studies included
- PRISMA
- Screening, data extraction and quality assessment in duplicate
- No time restrictions
- Primarily retrospective cohort studies included
Pooled result
As reported in the abstract
Prevalence of extrarenal manifestations of SLE
- Musculoskeletal involvement, range (most studies 46%-85%)
- 2% to 100%
- Discoid rash
- 5%-100%
- Malar rash
- up to 79%
- Photosensitivity
- 6.12%-29.3%
- RP
- 4.5%-15.2%
- Neuropsychiatric symptoms, especially depression
- up to 67.6%
Original publication
Systematic review of the reporting of extrarenal manifestations in observational studies of Saudi patients with systemic lupus erythematosus. Lupus Sci Med. Published 5 March 2025. doi:10.
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