Lupus & antiphospholipid syndrome
Prognostic value of the modified National Institute of health activity and chronicity scoring system in predicting end-stage kidney disease in Latin American lupus nephritis patients
Authors' conclusion
In Latin American LN patients, the mNIH activity and chronicity indices are associated with an increased risk of ESKD. Among the components of these indices, shorter time to ESKD was mainly driven by fibrinoid necrosis and fibrous crescents.
Study context
- Population
- Latin American patients with biopsy-proven lupus nephritis (LN)biopsy-proven LN
- Participants
- 412 patients
- Exposure
- Modified National Institute of Health (mNIH) activity and chronicity indices as predictors of end-stage kidney disease (ESKD)
- ESKDn = 84
- Outcome
- Progression to ESKD (estimated glomerular filtration rate (eGFR) < 15 mL/min/1.73 m² for ≥3 months, dialysis for >3 months, or kidney transplant)
Methodological detailsunivariable and multivariable Cox proportional hazards regression
- Univariable and multivariable Cox proportional hazards regression
Main finding
As reported in the abstract
Association of mNIH indices with ESKD (multivariable Cox, adjusted for age, sex, ethnicity, eGFR)
Hazard ratio (95% CI)
mNIH activity index
1.17(1.05–1.29)
mNIH chronicity index
1.21(1.05–1.40)
Observational data: associations, not effects.
Further findings
Index components and time to ESKD
| HR (95% CI) | ||
|---|---|---|
| Fibrinoid necrosis | 4.09 (1.54–10.86) | |
| Fibrous crescents | 2.36 (1.06–5.27) | |
| 0.050.21520Hazard ratio (log scale) |
| Outcome | ESKD | No ESKD | P value |
|---|---|---|---|
| mNIH activity index | 7 (range 5–10) | 4 (range 1–7) | P < 0.001 |
| mNIH chronicity index | 3 (range 1–5) | 0 (range 0–2) | P < 0.001 |
Original publication
Prognostic value of the modified National Institute of health activity and chronicity scoring system in predicting end-stage kidney disease in Latin American lupus nephritis patients. Lupus. Published 4 March 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →