Lupus & antiphospholipid syndrome
Global tuberculosis disease and infection in systemic lupus erythematosus patients: A systematic review and meta-analysis
Authors' conclusion
TB prevalence in SLE was relatively high and associated with GC.
Study context
- Population
- Systemic lupus erythematosus (SLE) patients; studies assessing tuberculosis (TB), PubMed, Science Direct, EBSCO and Web of Science from inception to April 30, 202327 studies
- Outcome
- Global prevalence of TB disease and TB infection in SLE
Pooled result
As reported in the abstract
TB disease prevalence
4%
95% CI 3–4%, n = 25 studies
TB infection prevalence
18%
95% CI 10–26%, n = 3 studies
Further pooled results
| Outcome | Mean difference (95% CI) | P value | |
|---|---|---|---|
| 1-year cumulative GC dose, SLE with TBvs without TBn = 3 | 2.56 (0.22–4.91) | P < 0.00001 | |
| −20246Difference (linear scale) |
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| TB with methylprednisolone pulse therapyMP pulse therapyvs No MP pulse therapyn = 3 | 2.11 (1.01–4.41) | P = 0.05 | |
| 0.20.5125Odds ratio (log scale) |
Pooled prevalence by type of TB disease
- Pulmonary TB
- 2% (95% CI: 2-3%, n = 20)
- Extrapulmonary TB
- 1% (95% CI: 1-2%, n = 17)
- Disseminated TB
- 1% (95% CI: 0-1%, n = 6)
Other immunosuppressive agents and TB
- Not significantly associated with TB
Original publication
Global tuberculosis disease and infection in systemic lupus erythematosus patients: A systematic review and meta-analysis. Lupus. Published 15 March 2024. doi:10.
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