Lupus & antiphospholipid syndrome
Comparison of Attainment and Protective Effects of Lupus Low Disease Activity State in Patients With Newly Diagnosed Versus Established Systemic Lupus Erythematosus
Main finding · LLDAS attainment (patients not in LLDAS at enrolment)Result — go to the resultHazard ratio 1.37 95% CI 1.16–1.61Authors' conclusion
LLDAS attainment is protective from flare in recent onset SLE. Significant protection from damage accrual was not observed because of low rates of damage accrual in the first years after SLE diagnosis.
Study context
- Population
- Patients with systemic lupus erythematosus (SLE) in a 13-country longitudinal cohort, 2013–2020
- Participants
- 4,106 patients
- Exposure
- Inception cohort vs noninception cohort
- Inceptionn = 680
- Outcome
- Association of LLDAS attainment with damage accrual and flare
Methodological detailsmultinational (13-country) longitudinal cohort, inception vs noninception cohort comparison, survival analyses
- Multinational (13-country) longitudinal cohort
- Inception vs noninception cohort comparison
- Survival analyses
Main finding
As reported in the abstract
LLDAS attainment (patients not in LLDAS at enrolment)
Hazard ratio
1.37
95% CI 1.16–1.61
P < 0.001
Inceptionvs Noninception
HR 1.37 (95% CI 1.16–1.61); P < 0.001
Observational data: associations, not effects.
Further findings
In LLDAS at enrolment
P < 0.001
- Organ damage accrual in inception cohort · median 2.2 years of follow-up
- 13.6% · 88
In Lupus Low Disease Activity State (LLDAS) at enrolment
- Three-quarters of both groups achieved LLDAS at least once during follow-up
Original publication
Comparison of Attainment and Protective Effects of Lupus Low Disease Activity State in Patients With Newly Diagnosed Versus Established Systemic Lupus Erythematosus. J Rheumatol. Published 15 March 2024. doi:10.
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