Lupus & antiphospholipid syndrome
Predictors of damage accrual by organ domain in systemic lupus erythematosus
Authors' conclusion
Risk factors for individual organ system damage accrual were highly varied in patients with SLE. Not all factors associated with domain-specific damage accrual were captured by the risk factors analysed for overall organ damage accrual.
Study context
- Population
- Patients with SLE in a 13-country longitudinal cohort, 2013–2020median follow-up 2.8 years
- Participants
- 3,449 patients
- Outcome
- Overall and domain-specific organ damage accrual (SLICC/ACR DI)
Methodological detailsmultinational (13 countries), longitudinal, multi-failure, multivariate models
- Multinational (13 countries)
- Longitudinal
- Multi-failure, multivariate models
Main finding
As reported in the abstract
Damage accrual in at least one domain · median 2.8 [IQR: 1.1, 5.6] years of follow-up
- Patients accruing damage in ≥1 domain
- 21% (n = 717)
- Musculoskeletal damage
- 6%
- Renal damage
- 5%
- Ocular damage
- 5%
- Neuropsychiatric damage
- 2.5%
- Other domains
- <2%
Observational data: associations, not effects.
Original publication
Predictors of damage accrual by organ domain in systemic lupus erythematosus. Rheumatology (Oxford). Published 18 November 2025. doi:10.
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