Lupus & antiphospholipid syndrome
Discordance Between Systemic Lupus Erythematosus Disease Activity Index Domain Weights and Their Association With Organ Damage Accrual
Authors' conclusion
Associations of SLEDAI-2K domains with damage accrual were variable and were discordant with domain weightings.
Study context
- Population
- Patients with systemic lupus erythematosus (SLE) attending a single centre, 2007–2016 (86.5% female, 51.5% White)
- Participants
- 266 patients5,538 visits
- Exposure
- SLEDAI-2K domains at visits during vs outside damage transition
- Outcome
- Association of SLEDAI-2K domains with damage transition (increase in SDI in the same year)
Methodological detailssingle-centre, visit-level analysis, Fisher exact test (univariable), generalized linear mixed-effect models (multivariable)
- Single-centre
- Visit-level analysis
- Fisher exact test (univariable)
- Generalized linear mixed-effect models (multivariable)
Main finding
As reported in the abstract
SLEDAI-2K domains positively associated with damage transition (all weights ≤4)
Odds ratio (95% CI)P value
Pericarditis
5.39(1.59–18.3)
P < 0.01Pleurisy
2.12(1.14–3.94)
P = 0.02Arthritis
1.40(1.02–1.94)
P = 0.04Leukopenia
1.52(1.04–2.24)
P = 0.03Observational data: associations, not effects.
Original publication
Discordance Between Systemic Lupus Erythematosus Disease Activity Index Domain Weights and Their Association With Organ Damage Accrual. Arthritis Care Res (Hoboken). Published 12 May 2026. doi:10.
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