Lupus & antiphospholipid syndrome
Antineutrophil cytoplasmatic antibodies (ANCA) in patients with systemic lupus erythematosus. A cross sectional study in Brazilian patients and review of literature
Authors' conclusion
The ANCA prevalence found in this Brazilian sample was within the range reported in the literature and these autoantibodies were more frequent in males and in patients with vasculitis.
Study context
- Population
- Brazilian patients with systemic lupus erythematosus (SLE)
- Participants
- 130 patients
- Outcome
- Presence of ANCA by indirect immunofluorescence (IIF) and its associations with clinical and serological outcomes
Methodological detailsliterature review
- Literature review
Main finding
As reported in the abstract
ANCA positivity by IIF
ANCA positive
29.9%
pANCA
17.6%
cANCA
11.5%
Observational data: associations, not effects.
Further findings
Literature review: ANCA positivity in SLE (22 studies)
- ANCA positivity by indirect immunofluorescence (IIF)
- 13% to 81.1%
- ANCA positivity by ELISA
- 0 to 22.2%
- ANCA associated with renal damage in the Asian population
- Other associations found in isolated studies, not consistently reported
Original publication
ANCA in patients with systemic lupus erythematosus. A cross sectional study in Brazilian patients and review of literature. Lupus. Published 20 March 2024. doi:10.
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