Lupus & antiphospholipid syndrome
Psychosis in patients with systematic lupus erythematosus: A systematic literature review and meta-analysis
Authors' conclusion
Observational studies have reported that psychosis in SLE is strongly associated with increased disease activity and immune dysregulation.
Study context
- Population
- Adult systemic lupus erythematosus (SLE) patients (studies with ≥10 adults, through November 2024)
- Participants
- 31,495 patients65 studies
- Outcome
- Prevalence of psychosis in adult SLE patients
Methodological detailsPRISMA, random-effects model
- PRISMA
- Random-effects model
Pooled result
As reported in the abstract
Pooled prevalence of psychosis in SLE
Pooled prevalence of psychosis in SLE patients, 95% CI 3.6%-5.5%
4.5%
Further pooled results
Pooled prevalence of psychosis in neuropsychiatric SLE (NPSLE) (subgroup)
- Pooled prevalence of psychosis among NPSLE patients, 95% CI 10.0%-37.6%
- 20.5%
Associated factors and presentation
- Psychosis frequently occurred within 2 years of SLE onset
- Strongly associated with higher SLE disease activity, positive anti-ribosomal P antibodies, aPL and complement consumption
- Delusions and hallucinations predominated among clinical presentations
Original publication
Psychosis in patients with systematic lupus erythematosus: A systematic literature review and meta-analysis. Lupus. Published 10 March 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →