Lupus & antiphospholipid syndrome
New IgG and IgA autoantibody specificities against DNA-binding and RNA-binding proteins discriminate systemic lupus erythematosus from health and non-lupus autoimmunity–could anti-LIN28A enhance precision in diagnostics?
Authors' conclusion
Novel autoantibodies validated in this study may enhance diagnostics and molecular characterisation in SLE.
Study context
- Population
- Patients with systemic lupus erythematosus (SLE), primary Sjögren's disease or systemic sclerosis and healthy controls in 2 independent cohorts (discovery and validation)2 independent cohorts
- Comparison
- SLE vs primary Sjögren's disease, systemic sclerosis and healthy controls
- Outcome
- New IgG and IgA autoantibodies specific for SLE
Methodological detailsautoantigen microarray screening, discovery and validation cohorts
- Autoantigen microarray screening
- Discovery and validation cohorts
Performance
As reported in the abstract
5 IgG autoantibodies (anti-LIN28A, anti-HNRNPA2B1, anti-HMG20B, anti-HMGB2, anti-TFCP2) and 4 IgA autoantibodies (anti-LIN28A, anti-HMG20B, anti-SUB1, anti-TFCP2) identified and validated; specificity for SLE
0.91-0.94
Positivity in differentially abundant autoantibody (daAAb) analysis between SLE and comparator groups
0.22-0.69
Further findings
IgG and IgA anti-LIN28A · 14-month follow-up
- Levels varied over follow-up in newly diagnosed SLE; metrics outperformed traditional markers such as anti-dsDNA
Clustering of SLE patients by autoantibody positivity
- 1 subgroup with seroreactivity against multiple antigens, 3 with varying reactivity, 1 with no reactivity
- Positivity: levels above the HC median plus 2 IQRs in the discovery cohort
Pathway analysis
- daAAb targets pointed to DNA-binding and RNA-binding and transcription functions
Original publication
New IgG and IgA autoantibody specificities against DNA-binding and RNA-binding proteins discriminate systemic lupus erythematosus from health and non-lupus autoimmunity–could anti-LIN28A enhance precision in diagnostics? Ann Rheum Dis. Published 14 May 2025. doi:10.
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