Lupus & antiphospholipid syndrome
Optical coherence tomography angiography findings of systemic lupus erythematosus patients and the effect of neuropsychiatric involvement on it
Authors' conclusion
SLE patients may have early subclinical vascular involvement leading to decreased RPCP-VD. A negative correlation between the SLEDAI-2K and pRNFLT in the temporal subsectors of all SLE patients may show an association between the disease activity and temporal pRNFL thinning. The presence of neuropsychiatric involvement may also be associated with decreased RPCP-VD and pRNFLT.
Study context
- Population
- Systemic lupus erythematosus (SLE) patients, including NPSLE, and healthy controls; right eyes examined by disc optical coherence tomography angiography (OCTA)64 right eyes
- Exposure
- SLE vs healthy controls
- SLEn = 36
- NPSLEn = 10
- Healthy controls (HCs)n = 28reference
- Outcome
- RPCP-VD and pRNFLT in all peripapillary sectors, and their association with SLEDAI-2K
Methodological detailscase-control
- Case-control
Main finding
As reported in the abstract
- No significant difference in peripapillary retinal nerve fiber layer thickness (pRNFLT) between SLE and HCs
- SLE vs HCs: P < 0.005
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| VD and pRNFLT, NPSLE vs non-NPSLENPSLE vs non-NPSLE · lower inferior-hemi VD | P = 0.001 |
| VD and pRNFLT, NPSLE vs non-NPSLENPSLE vs non-NPSLE · lower inferior-nasal VD | P = 0.003 |
| VD and pRNFLT, NPSLE vs non-NPSLENPSLE vs non-NPSLE · lower peripapillary pRNFLT | P = 0.012 |
| VD and pRNFLT, NPSLE vs non-NPSLENPSLE vs non-NPSLE · lower superior-hemi pRNFLT | P = 0.038 |
| VD and pRNFLT, NPSLE vs non-NPSLENPSLE vs non-NPSLE · lower inferior-hemi pRNFLT | P = 0.026 |
| VD and pRNFLT, NPSLE vs non-NPSLENPSLE vs non-NPSLE · lower inferior-nasal pRNFLT | P = 0.002 |
| VD and pRNFLT, NPSLE vs non-NPSLENPSLE vs non-NPSLE · lower inferior-temporal pRNFLT | P = 0.012 |
Correlation of SLEDAI-2K with OCTA findings
- No correlation between SLEDAI-2K and radial peripapillary capillary plexus vessel density (RPCP-VD) in any subsector
- Significant negative correlation between SLEDAI-2K and pRNFLT in tempo-inferior and inferior-temporal sectors
VD and pRNFLT, NPSLE vs non-NPSLE
- Negative correlation between NPSLE and pRNFLT
Original publication
Optical coherence tomography angiography findings of systemic lupus erythematosus patients and the effect of neuropsychiatric involvement on it. Lupus. Published 5 September 2024. doi:10.
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