Lupus & antiphospholipid syndrome
Changes in retinal and choroidal thickness and vascular density in patients with systemic lupus erythematosus: Assessed by optical coherence tomography angiography
Authors' conclusion
DVD and CCVD were decreased in the SLE and might be related to the disease activity.
Study context
- Population
- Patients with systemic lupus erythematosus (SLE) and control subjects; retinal and choroidal thickness and vascular density measured by optical coherence tomography angiography (OCTA)
- Participants
- 29 vs 25
- Exposure
- SLE vs control subjects
- SLEn = 29
- Controln = 25reference
- Outcome
- Retinal and choroidal thickness and vascular density (retinal thickness (RT), inner retinal thickness (IRT), outer retinal thickness (ORT), choroidal thickness (ChT), SVD, DVD, CCVD, FAZ, superficial FAZ (sFAZ), dFAZ) by OCTA
Methodological detailscase-control comparison
- Case-control comparison
Main finding
As reported in the abstract
- Superficial vascular density (SVD) significantly increased in SLE vs control
- p < .05
- Deep vascular density (DVD) and CCVD significantly decreased in SLE vs control
- p < .05
Observational data: associations, not effects.
Further findings
Discrimination of SLE from controls (ROC AUC)
- AUC of SVD
- 0.873
- AUC of DVD
- 0.729
- AUC of CCVD
- 0.727
Correlation of Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) scores with OCTA measures in SLE
- Deep FAZ (dFAZ), positive correlation
- r = 0.589, p = .001
- Foveal avascular zone (FAZ), positive correlation
- r = 0.451, p = .018
- DVD, negative correlation
- r = −0.491, p = .009
- CCVD, negative correlation
- r = −0.521, p = .005
Original publication
Changes in retinal and choroidal thickness and vascular density in patients with systemic lupus erythematosus: Assessed by optical coherence tomography angiography. Lupus. Published 30 December 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →