Lupus & antiphospholipid syndrome
Preclinical ocular changes in systemic lupus erythematosus patients by optical coherence tomography
Authors' conclusion
SD-OCT and OCTA can detect preclinical structural and microcirculatory changes in SLE patients.
Study context
- Population
- SLE patients and healthy volunteers assessed by spectral-domain optical coherence tomography (SD-OCT) and OCT angiography
- Participants
- 78 vs 80
- Exposure
- SLE patients vs healthy volunteers
- SLEn = 78
- Healthy volunteersn = 80reference
- Outcome
- Structural (macular and RNFL thickness, SD-OCT) and perifoveal vascular (vessel density, vascular perfusion, FAZ) parameters (OCTA)
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
SD-OCT structural and OCTA perifoveal vascular parameters
- Structural parameters by SD-OCT and perifoveal vascular parameters by OCT angiography (OCTA) decreased in SLE patients vs controls
Observational data: associations, not effects.
Further findings
OCTA parameters and macular thickness by disease duration
- OCTA parameters (vessel density (VD), vascular perfusion (VP), foveal avascular zone (FAZ) circularity) and macular thickness decreased with longer disease duration (>10 years)
Retinal nerve fibre layer (RNFL) thickness by aPL
- aPL presence associated with decreased RNFL thickness, mainly in inferior quadrants
RNFL thickness and OCTA flow in APS
- Patients developing APS showed decreased RNFL thickness and OCTA flow changes
SD-OCT and OCTA vs disease activity
- Not associated with disease activity
Foveal structural parameters by damage score
- Lower in patients with higher damage score
Original publication
Preclinical ocular changes in systemic lupus erythematosus patients by optical coherence tomography. Rheumatology (Oxford). Published 4 November 2022. doi:10.
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