Lupus & antiphospholipid syndrome
Relationship between retinal microvascular impairment and subclinical atherosclerosis in SLE
Authors' conclusion
Patients with SLE showed lower retinal VD and higher CV risk indicators compared with HCs. Among patients with SLE, QRISK3 Score and IMT were found to be independent risk factors for retinal vascular impairment
Study context
- Population
- Patients with SLE and healthy controls undergoing optical coherence tomography angiography (OCTA) and carotid US with intima media thickness (IMT) assessment
- Participants
- 43 vs 34
- Exposure
- SLE vs healthy controls
- SLEn = 43
- Healthy controls (HC)n = 34reference
- Outcome
- Relationship between retinal vascular impairment (OCTA vessel density) and IMT in SLE
Methodological detailsage-corrected and sex-corrected multivariate regression
- Age-corrected and sex-corrected multivariate regression
Main finding
As reported in the abstract
Independent risk factors for reduced retinal VD in SLE (age- and sex-adjusted multivariate analysis)
- QRISK3 Score independent risk factor for reduced retinal vessel density (VD)
- p=0.049
- IMT independent risk factor for reduced retinal VD
- p=0.039
- Deep whole VD negatively correlated with IMT (univariate, SLE)
- p=0.027
Observational data: associations, not effects.
Further findings
SLE vs HC differences
- Higher triglycerides in SLE
- P = 0.019
- Higher Triglycerides-Glucose (TyG) Index in SLE
- P = 0.035
- Higher ACC/AHA guidelines risk in SLE
- P = 0.001
- Higher Framingham Risk Scores in SLE
- P = 0.008
- Reduced superficial whole retinal VD in SLE
- P < 0.001
- Reduced deep whole retinal VD in SLE
- P = 0.005
Univariate correlates of deep whole VD in SLE
- Negative correlation with age
- P = 0.001
- Negative correlation with systolic blood pressure
- P = 0.011
- Negative correlation with QRISK3 Score
- P < 0.001
- Negative correlation with SLICC/ACR DI
- P = 0.006
- Negative correlation with apolipoprotein B
- P = 0.021
- Positive correlation with female sex
- P = 0.029
Original publication
Relationship between retinal microvascular impairment and subclinical atherosclerosis in SLE. Lupus Sci Med. Published 18 October 2023. doi:10.
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