Lupus & antiphospholipid syndrome

Systemic lupus erythematosus associated with human immunodeficiency virus (HIV) infection: a retrospective case-control study

Clin Exp RheumatolPublished Retrospective case-control study

Authors' conclusion

SLE and HIV infection appear to be a rare association. Patients with SLE-PLHIV seem to have more renal manifestations and autoimmune cytopenias than patients with SLE without HIV infection.

Study context

Population
Patients with systemic lupus erythematosus (SLE) and HIV diagnosed between 1975 and 2020 in four French hospitals
Comparison
SLE in people living with HIV vs matched SLE without HIV infection
  • SLE in patients living with HIV (SLE-PLHIV)n = 13
Outcome
Characteristics of SLE in patients living with HIV
Methodological detailsmatched 1:5 on age, sex and year of diagnosis, multicentre (four French hospitals)
  • Matched 1:5 on age, sex and year of diagnosis
  • Multicentre (four French hospitals)

Main finding

As reported in the abstract

Renal manifestations

P = 0.006

Observational data: associations, not effects.

Further findings

Autoimmune cytopenia

P = 0.04

OutcomeSLE-PLHIVSLE without HIVP value
Renal manifestations54 %— not stated in the abstractP = 0.006

— not stated in the abstract

Original publication

Systemic lupus erythematosus associated with HIV infection: a retrospective case-control study. Clin Exp Rheumatol. Published 17 October 2023. doi:10.55563/clinexprheumatol/ujg828

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