Lupus & antiphospholipid syndrome
B cell polygenic risk scores associate with anti-dsDNA antibodies and nephritis in systemic lupus erythematosus
Performance · dsDNA antibodiesResult — go to the resultOdds ratio 1.47 CI 1.07–2.01Authors' conclusion
High genetic burden related to B cell function is associated with dsDNA antibody development and LN.
Study context
- Population
- Female patients with SLE and healthy controls, genotyped with Illumina's Global Screening Array1,248 SLE, 400 controls
- Comparison
- High vs low SLE B cell PRS
- Outcome
- Double-stranded DNA (dsDNA) antibodies
Methodological detailspolygenic risk scores, case-control genotyping
- Polygenic risk scores
- Case-control genotyping
Performance
As reported in the abstract
Odds ratio
1.47
CI 1.07–2.01
P = 0.018
High B cell PRSvs Low B cell PRS
OR 1.47 (CI 1.07–2.01); P = 0.018
Further findings
| Outcome | OR (CI) | P value | |
|---|---|---|---|
| dsDNA antibodies by HLA-DRB1*03:01/15:01 risk haplotypes (subgroups)High B cell PRSvs Low B cell PRSDRB1*03/15 -/- | 0.99 (0.56–1.77) | P = 0.98 | |
| dsDNA antibodies by HLA-DRB1*03:01/15:01 risk haplotypes (subgroups)High B cell PRSvs Low B cell PRSDRB1*03/15 +/- or -/+ | 1.64 (1.06–2.54) | P = 0.028 | |
| dsDNA antibodies by HLA-DRB1*03:01/15:01 risk haplotypes (subgroups)High B cell PRSvs Low B cell PRSDRB1*03/15 +/+ | 4.47 (1.21–16.47) | P = 0.024 | |
| Low complement levels in DRB1*03/15 +/+ patients (subgroup) | 3.92 (1.22–12.64) | P = 0.022 | |
| LN prevalence, B cell activation PRS abovevs below third quartile | 1.32 (1.00–1.74) | P = 0.048 | |
| 0.050.21520Odds ratio (log scale) |
Original publication
B cell polygenic risk scores associate with anti-dsDNA antibodies and nephritis in systemic lupus erythematosus. Lupus Sci Med. Published 16 October 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →