Lupus & antiphospholipid syndrome
Interplay between polygenic risk score and solar insolation: Implication for systemic lupus erythematosus diagnosis and pathogenesis
Main finding · SLE risk, highest vs lowest SLE-PRS decileResult — go to the resultFold increase in SLE risk 10.98 95 % CI 3.773–31.952Authors' conclusion
Our study unveils the intertwined nature of UV insolation and polygenic risks in SLE.
Study context
- Population
- Participants from the Taiwan Precision Medicine Initiative, genotyped via the Affymetrix Genome-Wide TWB 2.0 SNP Array; SLE-PRS of 27 single nucleotide polymorphisms (SNPs) tailored for Taiwanese ancestry; solar insolation computed from residences
- Participants
- 1,800 vs 1,800
- Comparison
- Systemic lupus erythematosus (SLE) vs controls; highest vs lowest SLE-PRS decile; high vs low solar insolation
- SLEn = 1,800
- Controlsn = 1,800reference
- Outcome
- Associations between SLE-PRS, solar insolation and SLE (risk of SLE)
Methodological detailsgenetic association study, logistic regression, additive and multiplicative interaction analysis
- Genetic association study
- Logistic regression
- Additive and multiplicative interaction analysis
Main finding
SLE risk, highest vs lowest SLE-PRS decile
Fold increase in SLE risk
10.98
95 % CI 3.773–31.952
P < 0.001
Highest SLE-PRS decilevs Lowest SLE-PRS decile
fold increase in SLE risk 10.98 (95 % CI 3.773–31.952); P < 0.001
As reported in the abstract
- SLE patients showed decreased solar insolation
- P < 0.001
Observational data: associations, not effects.
Further findings
Solar insolation before diagnosis, highest vs lowest SLE-PRS decile · 1, 3, 6 and 12 months prior to diagnosis
- Significantly lower solar insolation in highest decile at 1 month
- P = 0.025
- Significantly lower solar insolation in highest decile at 12 months
- P = 0.004
Original publication
Interplay between polygenic risk score and solar insolation: Implication for systemic lupus erythematosus diagnosis and pathogenesis. Semin Arthritis Rheum. Published 10 August 2024. doi:10.
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