Lupus & antiphospholipid syndrome
Association of Autoantibody Concentrations and Trajectories With Lupus Nephritis Histologic Features and Treatment Response
Authors' conclusion
Baseline levels of anti-C1q and anti-dsDNA may serve as noninvasive biomarkers of proliferative LN, and anti-C1q may predict complete response at the time of kidney biopsy.
Study context
- Population
- Patients with SLE undergoing diagnostic kidney biopsy based on proteinuria; 268 diagnosed with lupus nephritis (LN)268 with LN
- Participants
- 279 patients
- Exposure
- Proliferative LN vs nonproliferative LN
- Proliferative LNn = 160
- Nonproliferative LNn = 108reference
- Outcome
- Association of circulating autoantibody concentrations (13 specificities by bead-based assay; anti-C1q by ELISA) with LN histologic class and treatment response
Methodological detailslongitudinal cohort, Accelerating Medicines Partnership LN cohort
- Longitudinal cohort
- Accelerating Medicines Partnership LN cohort
Main finding
As reported in the abstract
Autoantibody concentrations by LN class · baseline
- Proliferative LN associated with higher anti-C1q, anti-chromatin, anti-dsDNA and anti-ribosomal P concentrations vs nonproliferative LN
- Anti-C1q and anti-dsDNA independently associated with proliferative LN
Observational data: associations, not effects.
Further findings
| Outcome | Baseline anti-C1q | Baseline proteinuria |
|---|---|---|
| Prediction of complete response in proliferative LN · 12 months | ||
| AUC | 0.72 | 0.59 |
| P | P = 0.002 | P = 0.21 |
Autoantibody trajectories over 12 months
- All autoantibody levels except anti-La/SSB decreased in proliferative, but not membranous, LN with complete response
Original publication
Association of Autoantibody Concentrations and Trajectories With Lupus Nephritis Histologic Features and Treatment Response. Arthritis Rheumatol. Published 9 August 2024. doi:10.
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