Lupus & antiphospholipid syndrome
Trajectories of long-term estimated glomerular filtration rate (eGFR) and proteinuria in lupus nephritis: a real-world biopsy-proven cohort study
Authors' conclusion
Distinct long-term trajectories of eGFR and proteinuria exist in LN. Short-term responses in eGFR and proteinuria may not reliably predict long-term renal outcomes
Study context
- Population
- Adults with class III/IV (±V) lupus nephritis (LN), followed from initial renal biopsy
- Participants
- 215 adults
- Exposure
- eGFR trajectory classes
- Outcome
- Long-term eGFR trajectories and their association with 24-hour urine protein (24hUP) trajectories
Methodological detailssingle-centre, biopsy-proven, latent class trajectory models, multinomial logistic regression
- Single-centre
- Biopsy-proven
- Latent class trajectory models
- Multinomial logistic regression
Main finding
As reported in the abstract
eGFR trajectory membership
- eGFR late/persistent-decline trajectories associated with high-decreasing/increasing 24hUP trajectories
- P < 0.001
Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | |
|---|---|---|
| Predictor of persistent-decline: higher chronicity indexPersistent-declinevs Stable | 1.64 (1.24–2.18) | |
| 0.512Odds ratio (log scale) |
| Outcome | Stable | Late-decline | P value |
|---|---|---|---|
| Late-decline: baseline eGFR and proteinuric flaresLate-decline vs Stable · more frequent proteinuric flares | 25% | 91% | P < 0.01 |
- Predictor of persistent-decline: higher chronicity index — Persistent-decline: higher chronicity index
- p<0.01
- Predictor of persistent-decline: higher chronicity index — Persistent-decline: higher baseline serum creatinine
- p=0.03
- Late-decline: baseline eGFR and proteinuric flares — Late-decline: higher baseline eGFR
- p=0.03
- Predictor of persistent-decline: higher chronicity index: higher chronicity index independently predicted persistent-decline
24hUP trajectory membership
- Low-decreasing
- 81.5%
- High-decreasing
- 11.4%
- High-increasing
- 7.1%
Short-term response in patients with declining eGFR · within 12 months
- Complete proteinuria response within 12 months
- 48%
- Met criteria for complete renal response
- 38%
- Despite long-term eGFR deterioration
Original publication
Trajectories of long-term eGFR and proteinuria in lupus nephritis: a real-world biopsy-proven cohort study. Lupus Sci Med. Published 29 January 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →