Lupus & antiphospholipid syndrome
Validation of the revised definition of lupus low disease activity in patients with SLE
Authors' conclusion
The revised LLDAS definition demonstrated comparable clinical benefits
Study context
- Population
- Patients with SLE followed annually over 4 years
- Participants
- 299 patients
- Exposure
- Revised lupus low disease activity state (LLDAS) definition vs existing LLDAS definition
- Outcome
- Association of revised LLDAS with organ damage (SLICC/ACR DI), disease flares and quality of life (SF-36 PCS and MCS)
- Follow-up
- 4 years
Methodological detailsannual follow-up over 4 years, generalized estimating equations
- Annual follow-up over 4 years
- Generalized estimating equations
Main finding
As reported in the abstract
Associations of revised LLDAS with clinical outcomes
Organ damage (SLICC/ACR SDI), β
−2.922
95% CI −3.294 to −2.550P < 0.001
Disease flare risk, OR
0.207
95% CI 0.083–0.515P < 0.001
Mental health (SF-36 MCS), β
1.219
95% CI 0.114–2.323P = 0.031
Observational data: associations, not effects.
Original publication
Validation of the revised definition of lupus low disease activity in patients with SLE. Rheumatology (Oxford). Published 29 January 2026. doi:10.
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