Lupus & antiphospholipid syndrome
Prothrombotic Activation of Platelet Pannexin‐1 Channels in Antiphospholipid Syndrome
Authors' conclusion
PANX1 channels appear to be important mediators of platelet activation in APS.
Study context
- Population
- Platelets isolated from patients with persistently positive aPL, patients with SLE and healthy controls
- Participants
- 36 / 10 / 16
- Comparison
- Platelets from patients with persistently positive aPL vs patients with SLE vs healthy controls; effect of the PANX inhibitor carbenoxolone
- Antiphospholipid syndrome (APS)n = 36
- SLEn = 10
- Healthy controlsn = 16reference
- Outcome
- Extracellular ATP release from platelets; platelet signaling, P-selectin exposure and aggregation
Main finding
As reported in the abstract
Platelet ATP release, P-selectin exposure and aggregation
- Basal ATP release normalized with carbenoxolone
- P = 0.03
- Carbenoxolone reduced thrombin-induced ATP release
- P = 0.002
- Carbenoxolone reduced thrombin-induced surface P-selectin expression
- P = 0.02
- Carbenoxolone reduced convulxin-induced ATP release
- P = 0.0001
- Carbenoxolone reduced convulxin-induced surface P-selectin expression
- P = 0.0012
- APS IgG enhanced PANX1 phosphorylation at tyrosine-308 in control platelets
- P = 0.03
- APS IgG enhanced ATP release in control platelets
- P = 0.0004
- APS IgG boosted ADP-induced aggregation
- P = 0.0011
- Carbenoxolone reduced APS IgG-boosted aggregation
- P = 0.0007
Further findings
Calcium chelation with BAPTA-AM on APS IgG-mediated platelet activation
- Decreased ATP release
- P = 0.03
- Decreased P-selectin expression
- P = 0.0005
- Decreased aggregation
- P = 0.0007
P2X1 desensitization with α,β-MeATP on APS IgG-induced platelet activation
- Decreased P-selectin expression
- P = 0.0002
- Decreased aggregation
- P = 0.01
Original publication
Prothrombotic Activation of Platelet Pannexin‐1 Channels in Antiphospholipid Syndrome. Arthritis Rheumatol. Published 29 January 2026. doi:10.
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