Lupus & antiphospholipid syndrome
LncRNA XIST/miR-381-3P/STAT1 axis as a potential biomarker for lupus nephritis
Authors' conclusion
STAT1 is a key gene in the development of LN. In conclusion, lncRNA XIST, miR-381-3P, and STAT1 can be used as new molecular markers to assist in the diagnosis of LN
Study context
- Population
- Female patients with systemic lupus erythematosus (SLE) (validation cohort); Lupus nephritis (LN) gene expression microarrays from GEOfemale patients with SLE
- Participants
- 37 patients
- Outcome
- Differentially expressed genes and diagnostic value of the lncRNA XIST/miR-381-3P/STAT1 axis in LN
Methodological detailsGEO microarray datasets GSE157293 and GSE112943, protein-protein interaction (PPI) network, lncRNA-miRNA-mRNA regulatory network prediction, dual luciferase, RT-qPCR, ROC analysis
- GEO microarray datasets GSE157293 and GSE112943
- PPI network
- lncRNA-miRNA-mRNA regulatory network prediction
- Dual luciferase
- RT-qPCR
- ROC analysis
Performance
As reported in the abstract
Differential genes screened in GSE157293
133
Differential genes screened in GSE112943
2869
Differentially co-expressed genes
26
Core genes screened (STAT1, OAS2, OAS3, IFI44, DDX60, IFI44L)
6
Original publication
LncRNA XIST/miR-381-3P/STAT1 axis as a potential biomarker for lupus nephritis. Lupus. Published 9 August 2024. doi:10.
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