Lupus & antiphospholipid syndrome
Type I interferon and neutrophil transcripts in lupus nephritis renal biopsies: clinical and histopathological associations
Main findingResult — go to the resultRelative IFNα2 expression (mean ± SD as printed) 23.0 ± 16.2 vs 12.0 ± 14.8Authors' conclusion
IFN-I transcripts are expressed locally in kidneys from patients with proliferative LN and are associated with impaired renal function. Elevated defensin-α3 transcripts, a neutrophil product associated with neutrophil extracellular traps, may identify a driver of local IFN-I expression.
Study context
- Population
- Patients with various classes of LN undergoing kidney biopsy, and control kidney samples24 LN patients and 3 control samples
- Participants
- 6 / 14 / 4 / 3
- Comparison
- Proliferative LN vs membranous LN vs control kidneys
- Class IIIn = 6
- Class IVn = 14
- Class Vn = 4
- Controln = 3reference
- Outcome
- Expression of IFN-I and neutrophil transcripts (defensin-α3, FPRL-1) in kidney tissue and association with clinical and histopathological features
Main finding
As reported in the abstract
Relative IFNα2 expression (mean ± SD as printed)
23.0 ± 16.2 vs 12.0 ± 14.8
P = 0.04
- Defensin-α3 correlation with renal pathological activity indices
- r = 0.61, P = 0.02
- Defensin-α3 correlation with urinary protein levels
- r = 0.44, P = 0.048
- Defensin-α3 correlation with IFNα2 expression
- r = 0.50, P = 0.01
Original publication
Type I interferon and neutrophil transcripts in lupus nephritis renal biopsies: clinical and histopathological associations. Rheumatology (Oxford). Published 10 November 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →