Lupus & antiphospholipid syndrome
Characterisation of T and B cell receptor repertoire in patients with systemic lupus erythematosus
Authors' conclusion
In conclusion, our data revealed the specific changes of the TCR and BCR repertoires in SLE patients, which may provide new ideas for its prevention and treatment.
Study context
- Population
- Peripheral blood mononuclear cells of systemic lupus erythematosus (SLE) patients and healthy volunteers
- Comparison
- SLE patients vs healthy volunteers
- Outcome
- TCRβ and BCR-H repertoire (diversity, CDR3 length, V gene and CDR3 usage)
Methodological detailscase-control comparison with healthy volunteers, multiplex-PCR, Illumina sequencing and IMGT/HighV-QUEST
- Case-control comparison with healthy volunteers
- multiplex-PCR, Illumina sequencing and IMGT/HighV-QUEST
Main finding
As reported in the abstract
- Obvious reduction in BCR-H repertoire diversity and BCR-H CDR3 length in SLE
- Pre-selection BCR-H CDR3s in SLE also abnormally shortened
- No obvious change of T cell repertoire in SLE, incl. diversity and CDR3 length
- Skewed usage of V genes and CDR3 sequences in SLE
Original publication
Characterisation of T and B cell receptor repertoire in patients with systemic lupus erythematosus. Clin Exp Rheumatol. Published 7 November 2022. doi:10.
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