Lupus & antiphospholipid syndrome
T Cell Plasticity in Systemic Lupus Erythematosus Revealed by Large‐Scale T Cell Receptor Repertoire and Transcriptome Studies
Authors' conclusion
Our study identifies a Treg-associated Th1 state in human SLE, consistent with Treg cell to Th1 cell plasticity.
Study context
- Population
- Patients with autoimmune disease in the large-scale ImmuNexUT database, including systemic lupus erythematosus (SLE); 13 fine-grained T cell types6,392 samples
- Comparison
- SLE vs healthy controls
- SLEn = 117
- Outcome
- CD4+ T cell plasticity
Methodological detailsT cell receptor (TCR) repertoire and transcriptome profiling, replication in independent bulk and single-cell cohorts
- TCR repertoire and transcriptome profiling
- Replication in independent bulk and single-cell cohorts
Main finding
As reported in the abstract
- Strongest plasticity signal between eTreg cells and Th1 cells, replicated in an independent cohort
- SLE Th1 cells exhibited Treg-like TCR features and transcriptomic profiles
- eTreg cells showed increased clonotype sharing with Th1 cells vs healthy controls
- Th1 "Tregness" score positively correlated with SLE disease activity
Original publication
T Cell Plasticity in Systemic Lupus Erythematosus Revealed by Large‐Scale T Cell Receptor Repertoire and Transcriptome Studies. Arthritis Rheumatol. Published 2 June 2026. doi:10.
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