The prognostic value of neutrophile/lymphocyte ratio and serum chemerin to predict maternal-fetal complications in pregnant systemic lupus erythematosus patients

Medina, G; González-Cortés, FR; Sánchez-González, A; Vázquez-Rodríguez, JG; Ordoñez-González, I; Jiménez-Arellano, MP; García-Collinot, G; Morales-Montalvo, SI; Florez-Durante, OI; Cruz-Domínguez, MP; Colorado-Cruz, MF; Zurita-Muñoz, MA; Cruz-Arteaga, G; Sánchez-Enriquez, C; Jara, LJ; Saavedra, MÁ

doi:10.1177/09612033231206446

Lupus & antiphospholipid syndrome

The prognostic value of neutrophile/lymphocyte ratio and serum chemerin to predict maternal-fetal complications in pregnant systemic lupus erythematosus patients

LupusPublished 16 Oct 2023Analytical cross-sectional study of cases and controls

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Authors' conclusion

The NLR may help predict maternal-fetal complications in SLE pregnancy, constituting a marker of subclinical inflammation. Chemerin levels may be associated with preeclampsia.

Study context

Population: Pregnant patients with systemic lupus erythematosus (SLE), preeclampsia, and healthy pregnant women; Neutrophil-to-lymphocyte ratio (NLR) and chemerin determined between 20 and 25 weeks of gestation
Participants: 70 patients

Exposure: SLE vs preeclampsia vs healthy pregnant women
SLEn = 20
Preeclampsian = 20
Healthyn = 30reference
Outcome: Prognostic value of NLR and serum chemerin to predict maternal-fetal complications in pregnant SLE patients

Methodological detailscase-control, ROC curve analysis, Patients evaluated every 4-6 weeks until pregnancy resolution

Case-control
ROC curve analysis
Patients evaluated every 4-6 weeks until pregnancy resolution

Main finding

As reported in the abstract

Prediction of maternal-fetal complications (ROC)

Group	AUROC	AUROC 95% CI	P	Cut-off	Sensitivity	Specificity	PPV	NPV
NLR	0.715	0.56-0.86	p = .015	2.9	61%	78%	65%	75%
Chemerin	0.75	0.61-0.89	p = .001	>43 ng/mL	75%	72%	51.7%	87.8%

AUROC

NLR0.715

Chemerin0.75

AUROC 95% CI

NLR0.56-0.86

Chemerin0.61-0.89

P

NLRp = .015

Chemerinp = .001

Cut-off

NLR2.9

Chemerin>43 ng/mL

Sensitivity

NLR61%

Chemerin75%

Specificity

NLR78%

Chemerin72%

PPV

NLR65%

Chemerin51.7%

NPV

NLR75%

Chemerin87.8%

Observational data: associations, not effects.

Further findings

Serum chemerin between 20 and 25 weeks of gestation — SLE vs Healthy · across the three groups

P = 0.007

SLE26 ng/mLunlabelled interval 15.3–56.2

Preeclampsia96 ng/mLunlabelled interval 37.3–146.2

Healthy24.6 ng/mLunlabelled interval 15.3–47.4

Maternal complications

SLE55%

Preeclampsia100%

Healthy26%

Outcome	SLE	Preeclampsia	Healthy	P value
NLR between 20 and 25 weeks of gestationSLE vs Healthy · across the three groups	4 (unlabelled interval 2.3–5.6)	6 (unlabelled interval 4.6–9.2)	2.8 (unlabelled interval 2.1–2.9)	P = 0.0001
Fetal complications	60%	— withheld: not confirmed against the abstract	— withheld: not confirmed against the abstract

— withheld: the automatic checks could not confirm the value against the abstract

Maternal complications

Thrombocytopenia was the most frequent complication in all pregnant women, followed by hypertensive disorders

Fetal complications

Congenital malformations and prematurity were the most frequent fetal complications

Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.

Original publication

The prognostic value of neutrophile/lymphocyte ratio and serum chemerin to predict maternal-fetal complications in pregnant systemic lupus erythematosus patients. Lupus. Published 16 October 2023. doi:10.1177/09612033231206446

Read the original article ↗

Composed by AI from the published abstract and checked against it. How Briefs are made →