Lupus & antiphospholipid syndrome
Failing maternal–fetal tolerance in SLE (FaMaLE): a prospective cohort study for finding the molecular mechanisms behind pregnancy complications
Study context
- Population
- Women with SLE and healthy women in their first trimester of pregnancy (<14 weeks gestational age) at Amsterdam UMC
- Planned comparison
- Pregnant women with SLE vs healthy pregnant women
Methodological detailsstudy protocol, single-centre, Peripheral blood collected once per trimester, within 48 hours before delivery and 5-12 weeks post partum; placenta collected after delivery, Whole blood, PBMC and placenta samples freshly analysed by flow cytometry for immune cell composition, in relation to SLE disease course, pregnancy course and outcomes
- Study protocol
- Single-centre
- Peripheral blood collected once per trimester, within 48 hours before delivery and 5-12 weeks post partum; placenta collected after delivery
- Whole blood, PBMC and placenta samples freshly analysed by flow cytometry for immune cell composition, in relation to SLE disease course, pregnancy course and outcomes
No results yet. This paper sets out the design of a trial; its results are to come.
Original publication
Failing maternal–fetal tolerance in SLE (FaMaLE): a prospective cohort study for finding the molecular mechanisms behind pregnancy complications. Lupus Sci Med. Published 19 June 2025. doi:10.
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