Lupus & antiphospholipid syndrome
Sirtuin-1 in systemic lupus erythematosus: Frequency of keratoconjunctivitis sicca and relation to disease activity
Authors' conclusion
Serum SIRT1 levels were significantly elevated in patients with SLE and correlated with the presence of KCS and disease activity.
Study context
- Population
- Adult patients with SLE and healthy controls
- Participants
- 42 vs 42
- Exposure
- SLE patients vs healthy controls
- SLEn = 42
- Healthy controlsn = 42reference
- Outcome
- Serum SIRT1 levels (ELISA) and association with keratoconjunctivitis sicca (KCS) and disease activity (SLE Disease Activity Index (SLEDAI))
Main finding
As reported in the abstract
Serum SIRT1 levels
- SIRT1 correlation with disease activity
- r = 0.958, p < .001
- SIRT1 correlation with albuminuria
- r = 0.719, p < .001
- SIRT1 correlation with C3
- r = −0.843, p < .001
- SIRT1 correlation with C4
- r = −0.861, p < .001
- SIRT1 correlation with WBC count
- r = −0.616, p < .001
- SIRT1 correlation with platelet count
- r = −0.534, p < .001
- Higher SIRT1 in SLE with keratoconjunctivitis sicca (KCS) vs without
- p < .001
Observational data: associations, not effects.
Further findings
Independent predictors of disease activity (multivariable regression)
| OR (95% CI) | P value | ||
|---|---|---|---|
| Lower platelet count | −0.014 (−0.026 to −0.001) | P = 0.034 | |
| High SIRT1 levels | 0.838 (0.678–0.998) | P < 0.001 | |
| 0.512Odds ratio (log scale) |
Diagnostic performance of SIRT1
- AUC, SLE vs controls
- 1 (p < .001)
- AUC, identifying KCS in SLE
- 0.989 (p < .001)
Original publication
Sirtuin-1 in systemic lupus erythematosus: Frequency of keratoconjunctivitis sicca and relation to disease activity. Lupus. Published 19 June 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →