Lupus & antiphospholipid syndrome
Using linked electronic medical record-pharmacy data to examine lupus medication adherence: A retrospective cohort study
Authors' conclusion
Our study showed that obtaining linked EMR-pharmacy data is feasible with minimal missing data and can be leveraged in future adherence research.
Study context
- Population
- Patients with systemic lupus erythematosus (SLE) prescribed ≥1 SLE medication for ≥90 days (median age 36, 96% female, 58% Black)1,276 pharmacy records
- Participants
- 181 patients
- Outcome
- Adherence to SLE medications, defined by medication possession ratio (MPR) ≥80%
Methodological detailslinked electronic medical record (EMR)-pharmacy data, logistic regression
- Linked EMR-pharmacy data
- Logistic regression
Main finding
As reported in the abstract
Medication adherence (MPR ≥80%)
Weighted-average medication possession ratio (MPR)
57%
Adherent to hydroxychloroquine
45%
Adherent to ≥1 SLE medication
46%
Adherent to all SLE medications
32%
Observational data: associations, not effects.
Further findings
Agreement of pharmacy records between linked EMR-pharmacy data and vendor data
- Records overlapping between linked EMR-pharmacy data and vendor data
- 74%
- Records available from vendor but not through linked EMR-pharmacy data
- 9%
SLE medications prescribed
- Hydroxychloroquine
- 98%
- Azathioprine
- 34%
- Mycophenolate
- 33%
- Methotrexate
- 18%
- Belimumab
- 7%
Original publication
Using linked electronic medical record-pharmacy data to examine lupus medication adherence: A retrospective cohort study. Lupus. Published 3 September 2024. doi:10.
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