Lupus & antiphospholipid syndrome
Characteristic features of late-onset systemic lupus erythematosus: An observational study of data from the Lupus Registry of Nationwide Institutions
Authors' conclusion
We clarified that LoSLE was characterized by a higher male proportion, a lower frequency of skin rash and a tendency to organ damage.
Study context
- Population
- Patients with SLE meeting the 1997 ACR revised classification criteria, Lupus Registry of Nationwide Institutions, Japan929 enrolled
- Participants
- 895 patients
- Exposure
- Late-onset SLE vs early-onset SLE
- Late-onset systemic lupus erythematosus (LoSLE)n = 100
- Early-onset SLE (EoSLE)n = 795reference
- Outcome
- Characteristic features of LoSLE vs EoSLE
Methodological detailsmulticentre registry, multivariate binary logistic regression, multiple imputation
- Multicentre registry
- Multivariate binary logistic regression
- Multiple imputation
Main finding
As reported in the abstract
Male-to-female ratio
LoSLE
0.32
EoSLE
0.11
P < 0.001
Observational data: associations, not effects.
Further findings
Myositis at onset (SLEDAI component)
P = 0.031
Skin rash at onset (SLEDAI component)
P < 0.001
Alopecia at onset (SLEDAI component)
P = 0.012
Overall disease activity at onset
- No significant differences between the two groups
Immunosuppressant use (medical history)
- More commonly used in EoSLE
High SDI score at enrollment
- Late onset an independent risk factor; replicated in sub-analysis of patients with shorter time since onset
Original publication
Characteristic features of late-onset systemic lupus erythematosus: An observational study of data from the Lupus Registry of Nationwide Institutions. Lupus. Published 3 September 2024. doi:10.
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