Lupus & antiphospholipid syndrome
Old marker, new face: Anti-ribonucleoprotein (anti-RNP) as a sentinel of coronary and peripheral endothelial dysfunction in systemic lupus erythematosus
Authors' conclusion
High anti-RNP titres are significantly associated with subclinical coronary microvascular impairment and peripheral capillary architectural changes in SLE.
Study context
- Population
- Patients with SLE meeting American College of Rheumatology (ACR)/Systemic Lupus International Collaborating Clinics (SLICC) criteria at a tertiary hospital
- Participants
- 70 patients
- Exposure
- Anti-RNP titres in relation to coronary (coronary flow velocity reserve (CFVR)) and peripheral (nailfold dermoscopy) microvascular function
- High disease activityn = 45
- Low activityn = 25reference
- Outcome
- Mean CFVR values and presence of dermoscopic abnormalities (capillary drop-out, tortuosity and density) in relation to anti-RNP titres
Methodological detailssingle-centre (tertiary hospital)
- Single-centre (tertiary hospital)
Main finding
As reported in the abstract
Negative correlation of anti-RNP with CFVR
r=−0.30
Negative correlation of anti-RNP with stress ejection fraction (EF)
r=−0.33
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Cardiac function by disease activity | P < 0.05 |
- Cardiac function by disease activity: lower EF and CFVR, higher Wall Motion Score Index with high activity
Correlation of anti-RNP with Systemic Lupus Erythematosus Disease Activity Index (SLEDAI)
- Positive correlation with SLEDAI
- r=0.653, p<0.001
- Positive correlation with ESR, proteinuria and RP; negative with C3 and C4 (p<0.05)
Clinical manifestations
- Elevated anti-RNP significantly associated with myositis and avascular necrosis (p<0.05)
Original publication
Old marker, new face: anti-RNP as a sentinel of coronary and peripheral endothelial dysfunction in systemic lupus erythematosus. Lupus Sci Med. Published 29 June 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →