Lupus & antiphospholipid syndrome
Genetic load in incomplete lupus erythematosus
Authors' conclusion
Patients with ILE and SLE have comparable genetic loads of SLE risk loci, suggesting similar genetic predispositions between these conditions.
Study context
- Population
- European American patients with SLE, incomplete lupus erythematosus (ILE) and healthy controls
- Participants
- 170 / 169 / 119 / 133
- Comparison
- SLE risk allele genetic load in ILE and SLE vs healthy controls
- SLEn = 170
- ILEn = 169
- ILESLICCn = 119
- Healthy controlsn = 133reference
- Outcome
- SLE risk allele genetic load (unweighted: sum of risk alleles; weighted: sum multiplied by ln of published OR), based on 99 SLE-associated risk alleles
Methodological detailsEuropean American patients, unweighted and weighted genetic load of 99 SLE risk alleles, ROC analysis
- European American patients
- Unweighted and weighted genetic load of 99 SLE risk alleles
- ROC analysis
Main finding
As reported in the abstract
Median unweighted SLE risk allele genetic load
ILE
81
median
SLE
80
median
ILESLICC
80
median
Healthy controls
78
median
ILE vs Healthy controls: P = 0.01 · SLE vs Healthy controls: P = 0.02 · ILESLICC vs Healthy controls: P = 0.14
Observational data: associations, not effects.
Further findings
Median
| Outcome | SLE | ILE | ILESLICC | Healthy controls | P value |
|---|---|---|---|---|---|
| Median weighted SLE risk allele genetic loadILE vs Healthy controls | 16.29 | 16.3 | 16.05 | 15.76 | P = 0.001 |
| Median weighted SLE risk allele genetic loadSLE vs Healthy controls | P = 0.0006 | ||||
| Median weighted SLE risk allele genetic loadILESLICC vs Healthy controls · not statistically significant | P = 0.07 |
Genetic load, ILE vs SLE
- AUC for differentiating ILE from SLE (ROC analysis)
- 0.51, p=0.78
- Median genetic load did not significantly differ between ILE and SLE
Original publication
Genetic load in incomplete lupus erythematosus. Lupus Sci Med. Published 4 January 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →