Lupus & antiphospholipid syndrome
The association of serum magnesium with infection in new-onset systemic lupus erythematosus patients
Authors' conclusion
Hypermagnesemia was rare in new-onset SLE patients. Hypomagnesemia was common and was associated with an increased risk of infection in new-onset SLE patients.
Study context
- Population
- Hospitalised new-onset systemic lupus erythematosus (SLE) patients, single centre, 2012–2021 (81.7% female; average age at diagnosis 43.7 years)
- Participants
- 476 patients
- Exposure
- Infection vs noninfection in hospitalised new-onset SLE
- Infectionn = 299
- Noninfectionn = 177reference
- Outcome
- Association of hypomagnesemia with infection
Methodological detailssingle-centre, logistic regression
- Single-centre
- Logistic regression
Main finding
As reported in the abstract
Prevalence of hypomagnesemia (<0.70)
P = 0.001
- Hypomagnesemia associated with increased risk of infection (logistic regression)
- P = 0.001
Observational data: associations, not effects.
Further findings
Baseline serum magnesium
P = 0.000
| Outcome | Infection | Noninfection |
|---|---|---|
| Mortality | 20 events | — not stated in the abstract |
— not stated in the abstract
- Baseline serum magnesium — Overall baseline serum magnesium
- 0.819 mmol/L
- Mortality — Overall mortality
- 4.4% (21/476)
Magnesium status prevalence in all new-onset SLE: hypomagnesemia (<0.70), normomagnesemia (0.70-1.10), hypermagnesemia (>1.10)
- Hypomagnesemia
- 14.3%
- Normomagnesemia
- 83.4%
- Hypermagnesemia
- 2.3%
Poor prognosis with hypomagnesemia (logistic regression)
- Hypomagnesemia associated with poor prognosis
- P = 0.015
Original publication
The association of serum magnesium with infection in new-onset systemic lupus erythematosus patients. Lupus. Published 3 January 2023. doi:10.
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