Lupus & antiphospholipid syndrome
Association of Sleep Deprivation and the Risk of Developing Systemic Lupus Erythematosus Among Women
Main finding · Incident SLEResult — go to the resultAdjusted hazard ratio 2.47 95% CI 1.29–4.75Authors' conclusion
Chronic low sleep duration was associated with higher SLE risk, with stronger effects among those with bodily pain and depression
Study context
- Population
- Women in the Nurses' Health Study (1986–2016) and NHSII (1989–2017) cohorts187 incident systemic lupus erythematosus (SLE) cases
- Participants
- 186,072 women
- Exposure
- Chronic low sleep duration vs >7-8 hours/night
- Outcome
- Incident SLE
Methodological detailsadjusted Cox regression, cumulative average sleep duration (categorical)
- Adjusted Cox regression
- Cumulative average sleep duration (categorical)
Main finding
As reported in the abstract
Adjusted hazard ratio
2.47
95% CI 1.29–4.75
≤5 hours/nightvs >7-8 hours
aHR 2.47 (95% CI 1.29–4.75)
Observational data: associations, not effects.
Further findings
| Outcome | Estimate | |
|---|---|---|
| Incident SLE, 4-year lagged analysisLagged 4 years | HRadj 3.14 (95% CI 1.57–6.29) | |
| Incident SLE, further adjusted for shiftwork, bodily pain and depression | HRadj 2.13 (95% CI 1.11–4.10) | |
| Additive interaction: low sleep duration and high bodily pain (SF-36 score <75)Both risk factorsvs Neither | HR 2.97 (95% CI 1.86–4.75) | |
| 0.10.31310Ratio (log scale) |
- Additive interaction: low sleep duration and high bodily pain (SF-36 score <75) — Attributable proportion (AP), 95% CI 40%, 87%
- 64%
Interaction: low sleep duration and depression
- Attributable proportion (AP), 95% CI 49%, 88%
- 68%
- HR for SLE, 95% CI 1.64, 4.85
- 2.82
Original publication
Association of Sleep Deprivation and the Risk of Developing Systemic Lupus Erythematosus Among Women. Arthritis Care Res (Hoboken). Published 29 December 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →