Lupus & antiphospholipid syndrome
Systematic review of fatigue assessment instruments for SLE: psychometric validation with COSMIN 2.0 guidelines
Authors' conclusion
A critical gap exists in fully validated, high-quality SLE-specific PROMs for fatigue assessment. FACIT-Fatigue is the most viable tool for this population but requires further rigorous psychometric validation.
Study context
- Population
- SLE patients; studies developing/psychometrically validating SLE fatigue-specific PROMs, eight databases from inception to 12 June 202615 studies · 6 PROMs
- Outcome
- Methodological quality and psychometric properties of PROMs for fatigue assessment in SLE
Methodological detailsCOSMIN 2.0 guidelines, modified Grading of Recommendations Assessment, Development and Evaluation (GRADE)
- COSMIN 2.0 guidelines
- Modified GRADE
Pooled result
As reported in the abstract
- FACIT-Fatigue most promising: high-quality evidence for five core psychometric properties (content validity, structural validity, internal consistency, construct validity hypothesis testing, responsiveness)
- 5
Original publication
Systematic review of fatigue assessment instruments for SLE: psychometric validation with COSMIN 2.0 guidelines. Rheumatology (Oxford). Published 20 August 2026. doi:10.
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