Lupus & antiphospholipid syndrome
Maternal and fetal outcomes in pregnancy complicated by pre-existing lupus nephritis: Insights from a developing country Pakistan
Authors' conclusion
The maternal and fetal outcomes in pre-existing LN depend on the disease activity at the time of conception. No correlation was found between International Society of Nephrology/Renal Pathology Society (ISN/RPS) classes of LN and adverse disease and pregnancy outcomes.
Study context
- Population
- Women with biopsy-proven lupus nephritis (LN) who conceived at least 6 months after diagnosis, Sindh Institute of Urology and Transplantation (SIUT), Pakistan, July 1998–June 2018
- Participants
- 52 women89 pregnancies
- Outcome
- Maternal and fetal outcomes
- Follow-up
- Minimum 12 months after child birth
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Pregnancy outcomes (of 89 pregnancies)
- Successful pregnancies
- 56 (62.9%)
- Fetal complications (spontaneous abortion, stillbirth, perinatal death, intrauterine growth retardation (IUGR))
- 33 (37.07%)
- Vaginal deliveries
- 33 [58.92%]
- Caesarean sections
- 23 [41.07%]
- Renal flare
- 33 (37.1%)
- Pre-eclampsia
- 15 (16.9%)
Observational data: associations, not effects.
Further findings
Maternal and fetal outcomes by LN class (proliferative LN in 56 (62.9%) cases)
- No significant differences in relation to LN classes
- P = 0.58
Disease outcomes by disease activity at conception · 12 months
- Significantly poor in those with active disease at conception
- P < 0.05
Maternal death
- Maternal deaths
- 1
Safety
Renal outcomes · 12 months
- Deterioration in renal function
- 10 (11.2%)
- Dialysis-dependent
- 5 (5.6%)
Original publication
Maternal and fetal outcomes in pregnancy complicated by pre-existing lupus nephritis: Insights from a developing country Pakistan. Lupus. Published 9 April 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →