Lupus & antiphospholipid syndrome
Association between antiphospholipid antibodies and diffuse alveolar haemorrhage risk in systemic lupus erythematosus: a systematic review and meta-analysis
Pooled result · DAH, any aPL positivityResult — go to the resultOdds ratio 1.76 95% CI 1.24–2.49Authors' conclusion
In patients with SLE, aPL positivity increases the risk of DAH compared with aPL-negative patients, particularly in those positive for LA and anticardiolipin IgG.
Study context
- Population
- Patients with SLE; databases searched from inception to February 2024
- Participants
- 7,746 patients9 studies
- Comparison
- aPL-positive vs aPL-negative patients with SLE
- aPL-positiven = 2,016
- Outcome
- DAH
Methodological detailsfixed-effect models
- Fixed-effect models
Pooled result
DAH, any aPL positivity
Odds ratio
1.76
95% CI 1.24–2.49
aPL-positivevs aPL-negative
OR 1.76 (95% CI 1.24–2.49)
As reported in the abstract
Further pooled results
| Outcome | OR (95% CI) | |
|---|---|---|
| DAH by LA positivityLA positivevs LA negativeI2 = 35% · fixed-effect models | 1.76 (1.06–2.93) | |
| DAH by anticardiolipin IgG positivityPositive anticardiolipin IgGvs negative for anticardiolipin IgGI2 = 0% · fixed-effect models | 1.62 (1.13–2.34) | |
| DAH by APS diagnosisAPSvs without APSI2 = 0% · fixed-effect models | 2.46 (1.23–4.92) | |
| 0.20.5125Odds ratio (log scale) |
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Association between antiphospholipid antibodies and diffuse alveolar haemorrhage risk in systemic lupus erythematosus: a systematic review and meta-analysis. Rheumatology (Oxford). Published 18 November 2024. doi:10.
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