Lupus & antiphospholipid syndrome
Ultraprocessed Food Intake and Risk of Systemic Lupus Erythematosus Among Women Observed in the Nurses’ Health Study Cohorts
Main finding · Incident SLE, UPF servings per dayResult — go to the resultPooled MV HR 1.56 95% CI 1.04–2.32Authors' conclusion
Higher cumulative average daily UPF intake was associated with >50% increased SLE risk and with doubled risk for anti-dsDNA antibody in patients with SLE.
Study context
- Population
- Women in the Nurses' Health Study cohorts (Nurses' Health Study (NHS) 1984–2016; NHSII 1991–2017); mean baseline age ≈50 years (NHS) and ≈36 years (NHSII); 93% White212 incident systemic lupus erythematosus (SLE)
- Participants
- 204,175 women
- Exposure
- Third vs first tertile of cumulatively updated daily ultraprocessed food (UPF) intake
- Outcome
- Incident SLE (self-reported doctor-diagnosed, confirmed by medical records)
Methodological detailstime-varying Cox regression, multivariable-adjusted
- Time-varying Cox regression
- Multivariable-adjusted
Main finding
Incident SLE, UPF servings per day
Pooled MV HR
1.56
95% CI 1.04–2.32
P = 0.03
Third UPF tertilevs First UPF tertile
pooled MV HR 1.56 (95% CI 1.04–2.32); P = 0.03
As reported in the abstract
Observational data: associations, not effects.
Further findings
Anti-dsDNA antibody–positive SLE
- Servings per day pooled MV HR
- 2.05 (95% CI 1.15-3.65; P = 0.01)
Sugar-sweetened/artificially sweetened beverages and SLE risk
- Third vs first tertile MV HR
- 1.45 (95% CI 1.01-2.09)
Absolute (servings or total) vs percentage of total intake
- Results stronger for absolute (servings or total) than percentage of total intake
Interaction with body mass index (BMI)
- No BMI interactions were observed
Original publication
Ultraprocessed Food Intake and Risk of Systemic Lupus Erythematosus Among Women Observed in the Nurses’ Health Study Cohorts. Arthritis Care Res (Hoboken). Published 30 July 2024. doi:10.
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