Lupus & antiphospholipid syndrome
Impact of disease activity patterns on health-related quality of life (HRQoL) in patients with systemic lupus erythematosus (SLE)
Main finding · Physical HRQoL (SF-36 physical component summary), multivariableResult — go to the resultRegression coefficient 3.2 95% CI 0.51–5.89Authors' conclusion
A persistently quiescent disease may have a positive impact on patients' physical HRQoL and on depressive symptoms. However, this condition appears insufficient to obtain a significant improvement in mental health, fatigue and disease burden among patients with SLE.
Study context
- Population
- Adult SLE outpatients enrolled 2017–2021, single centre222 with complete 3-year data
- Participants
- 241 outpatients
- Exposure
- Long quiescent (LQ) disease vs chronically active (CA)/relapsing-remitting (RR) disease in the 3 years before enrolment
- Outcome
- HRQoL (SF-36, Lupus Impact Tracker, Functional Assessment of Chronic Illness Therapy (FACIT), Hospital Anxiety and Depression Scale (HADS)) by disease activity pattern
- Follow-up
- 3 years before enrolment
Methodological detailsmonocentric, analysis of prospectively collected data, multivariable analysis
- Monocentric
- Analysis of prospectively collected data
- Multivariable analysis
Main finding
As reported in the abstract
Physical HRQoL (SF-36 physical component summary), multivariable
Regression coefficient
3.2
95% CI 0.51–5.89
P = 0.02
Observational data: associations, not effects.
Further findings
Factors associated with worse HRQoL at baseline
- Fibromyalgia, organ damage, age and daily GC dose associated with worse HRQoL
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Impact of disease activity patterns on health-related quality of life (HRQoL) in patients with systemic lupus erythematosus (SLE). Lupus Sci Med. Published 29 July 2024. doi:10.
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