Lupus & antiphospholipid syndrome
Changes in the incidence and prevalence of systemic lupus erythematosus between 1990 and 2020: an observational study using the Clinical Practice Research Datalink (CPRD)
Authors' conclusion
The observed fivefold increase in prevalence of SLE over the last 30 years, in the context of a modest decline in incidence rate, may suggest improved outcomes in SLE
Study context
- Population
- Patients with systemic lupus erythematosus (SLE) in the UK, CPRD, 1990–20205,278 incident cases
- Participants
- 9,443 patients
- Outcome
- Incidence (per 100 000 person-years) and point prevalence (per 100 000, mid-year) of SLE
- Follow-up
- 1990-2020
Methodological detailscase ascertainment algorithm, stratified by sex
- Case ascertainment algorithm
- Stratified by sex
Main finding
As reported in the abstract
Overall SLE incidence rate
Overall incidence rate, cases per 100 000 person-years
5.47
95% CI 5.33 to 5.62
Observational data: associations, not effects.
Further findings
Point prevalence of SLE per 100 000 · 1990 and 2020
- Point prevalence in 1990, per 100 000
- 21.4 (95% CI 17.68 to 25.67)
- Point prevalence in 2020, per 100 000
- 107.14 (95% CI 103.26 to 111.12)
Incident cases by sex
- Incident cases, women
- 4538
- Incident cases, men
- 740
Original publication
Changes in the incidence and prevalence of systemic lupus erythematosus between 1990 and 2020: an observational study using the Clinical Practice Research Datalink (CPRD). Lupus Sci Med. Published 27 July 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →